TcPO₂ is one of the quickest reality-checks for healing potential:
✅ Target: TcPO₂ > 30 mm Hg for predictable healing
⚠️ < 30 mm Hg → biologic processes slow (collagen synthesis, fibroblast activity, host defense)
⛔ ~13 mm Hg or lower → closure is unlikely unless you restore perfusion (often revascularization) and/or use adjunct oxygen approaches
Limb preservation starts with physiology, not products.
Indicative Ref
Sayadi, L. R., Banyard, D. A., Ziegler, M. E., Obagi, Z., Prussak, J., Klopfer, M. J., Evans, G. R., & Widgerow, A. D. (2018). Topical oxygen therapy & micro/nanobubbles: a new modality for tissue oxygen delivery. International wound journal, 15(3), 363–374.
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