Beyond tissue removal, sharp surgical debridement may induce a form of taxonomic depletion within the chronic wound microbiome.
In DFUs, metagenomic data suggest that successful debridement is associated with a shift in the wound microbial milieu, particularly with depletion of anaerobic taxa in wounds that go on to heal.
At the same time, strain-level analyses of S. aureus suggest a possible distinction between generalist strains found across healing trajectories and specialist strains associated with non-healing wounds, with phage-mediated genomic diversification potentially contributing to these differences.
Viewed through a metagenomic lens, debridement may therefore represent more than tissue removal alone: it may help destabilize a chronic non-healing microbial ecology and support transition toward a more healing-permissive environment.
https://lnkd.in/dVMNXg6n Watch (22min onwards)
Dr. Elizabeth Grice’s 👏
(Elizabeth Grice, PhD, delivers the 2019 SID State of the Art Plenary Lecture III: Skin Microbiome: Opposing Roles in Barrier Function, Inflammation and Repair).
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